Arrowhead Pharmaceuticals, Inc.
(Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them.
Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes.
RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein.
Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease.
The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics.
Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.
Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The intern in the Development Chemistry Group will be focusing on the development of a scale down model for a new Manufacturing process.
This position will provide experience with organic synthesis & wet chemistry techniques, engineering/building a small-scale reaction system, process optimization and transferring a process for use in a manufacturing setting.
The ideal candidate will be pursuing their bachelor's degree in chemistry or chemical engineering and will have completed organic chemistry lab requirements by summer 2024.
Responsibilities
Evaluate differing stationary phases using High Performance Liquid Chromatography
Work closely with an associate scientist to execute and develop optimization of the Dr.
Oligo 48 for small scale processing of oligonucleotides
Perform reactions related to oligonucleotide synthesis
Analyze oligonucleotides using standard analytical methods (LC-MS)
Maintain a well-documented laboratory notebook
Present findings from the summer research project to the PD team during group meeting(s)
Requirements:
Currently enrolled student at an Accredited University or College and majoring in Chemistry or Engineering
Excellent verbal and written communication skills
Strong problem-solving skills
Eagerness to learn new techniques
Ability to work in a lab setting for prolonged periods of time
Ability to wear personal protective equipment as required
Must be able to lift 15 pounds at a time
Preferred:
Junior or Senior academic status at start of internship Summer 2024
Have successfully completed 2 semesters (each) of General Chemistry (with lab) and Organic Chemistry (with lab)
Basic laboratory skills such as: lab notebook recording, use of analytical instrumentation, analysis and interpretation of data, and safe lab practices
Prior research experience in either an academic or industrial setting, ideally in an organic synthesis or engineering laboratory
The hourly pay rate for this role is $19 per hour.
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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